Iranian state media says the death toll from a strike on a girls' school has climbed to 165

Iranian state media says the death toll from a strike on a girls’ school in the country’s south has climbed to 165. The Israeli military said it was not aware of any strikes in that area, and the U.S. military said it was looking into the reports. The state-run IRNA news agency quoted a local prosecutor as saying another 96 people were wounded in the strike. THIS IS A BREAKING NEWS UPDATE. AP’s earlier story follows below. DUBAI, United Arab Emirates — Iran vowed revenge Sunday after the killing of its supreme leader and traded strikes with Israel as part of a widening war prompted by a surprise U.S. and Israeli bombardment. The U.S. military said three service members have been killed, the first known American casualties from the conflict. Blasts in Tehran sent a huge plume of smoke into the sky in an area of government buildings. Iranian authorities say more than 200 people have been killed since the start of the U.S. and Israeli strikes that killed Ayatollah Ali Khamenei and other senior leaders. Iran fired missiles at targets in Israel and Gulf Arab states in retaliation while Israel pledged “non-stop” strikes against Iran’s leaders and military. PHOTOS: Iranian state media says the death toll from a strike on a girls' school has climbed to 165 In Israel, loud explosions caused by missile impacts or interceptions could be heard in Tel Aviv. Israel’s rescue services said nine people were killed and 28 wounded in a strike that hit a synagogue in the central town of Beit Shemesh, bringing the overall death toll in the country to 11. Eleven people were still missing after the strike, police said, as rescue crews combed the rubble. The strikes and counterattacks underscored how the killing of Khamenei, and U.S. President Donald Trump ’s calls for the overthrow of the decades-old Islamic Republic, carried the potential for a prolonged conflict that could envelop the Middle East. It also represents a startling show of military might for an American president who swept into office on an “America First” platform and vowed to keep out of “forever wars.” Streets of Tehran are largely deserted In Tehran, there was little sign that Iranians had heeded Trump’s call for an uprising against the government. The streets were largely deserted as people sheltered during heavy airstrikes, witnesses told The Associated Press, speaking anonymously for fear of retribution. The paramilitary Basij, which has played a central role in crushing protests, has set up checkpoints across the city, they said. The U.S. military said three service members were killed and five others seriously wounded, without providing further details. It said several others suffered minor injuries and concussions. In the 12-day war last June, Israeli and American strikes greatly weakened Iran’s air defenses, military leadership and nuclear program. But the killing of Khamenei, who had ruled Iran for more than three decades, creates a leadership vacuum, increasing the risk of regional instability. The CIA had been tracking the movements of senior Iranian leaders, including Khamenei, for months, according to a person familiar with the operation who was not authorized to comment publicly and spoke on condition of anonymity. The intelligence was shared with Israeli officials, and the timing of the strikes was adjusted in part because of that information, the person said. The New York Times earlier reported about the CIA’s efforts ahead of the Israeli-U.S. strikes. Iranian President Masoud Pezeshkian said in a prerecorded message that a new leadership council had begun its work. The country’s foreign minister, Abbas Araghchi, said a new supreme leader would be chosen in “one or two days.” Iran vows revenge for Khamenei killing As word spread of Khamenei’s death, some in Tehran could be seen cheering from rooftops, witnesses said. Others mourned as a black flag was raised over the Imam Reza shrine in Mashhad. “You have crossed our red line and must pay the price,” Iran’s parliamentary speaker, Mohammad Bagher Qalibaf, said in a televised address. “We will deliver such devastating blows that you yourselves will be driven to beg.” Trump warned against retaliation. “THEY BETTER NOT DO THAT,” he said in a social media post. “IF THEY DO, WE WILL HIT THEM WITH A FORCE THAT HAS NEVER BEEN SEEN BEFORE!” In a sign of how the attack could stoke regional unrest, hundreds of people stormed the U.S. Consulate in Pakistan’s port city of Karachi. Police and paramilitary forces used batons and fired tear gas to disperse the crowd, and at least nine people were killed in the clashes, authorities said. Iran retaliates with missiles and drone attacks As U.S. and Israeli strikes have pounded Iran, the Islamic Republic has retaliated with missiles and drone attacks on Israel and nearby Arab Gulf countries hosting U.S. forces. The air war could rattle global markets, particularly if Iran makes the Strait of Hormuz unsafe for commercial traffic. Around 20% of the world’s traded oil passes through the vital waterway. While Iran struck U.S. bases in Bahrain and the United Arab Emirates, the attacks have also hit outside of military installations, including a hotel in the Emirati city of Dubai, and Kuwait’s international airport. At least four people have been killed in strikes on Gulf countries. Araghchi, Iran’s foreign minister, blamed such strikes on the U.S. and Israel for starting the war. He said he had spoken to his counterparts in the Gulf countries and urged them to pressure the U.S. and Israel to end it. Israel’s Defense Minister Israel Katz said Sunday that Israel will have “a non-stop air train” of strikes against Iranian military and leadership targets. The U.S. military said it had struck an Iranian warship at a port on the Gulf of Oman that was now sinking. Flights across the Middle East were disrupted, and air defense fire thudded over Dubai. The United Arab Emirates’ commercial capital has long drawn business and expatriates by billing itself as a safe haven in a volatile region. Iran forms council to govern until a new supreme leader is chosen As supreme leader, Khamenei had final say on all major policies since 1989. He led Iran’s clerical establishment and the Revolutionary Guard, the two main centers of power in the governing theocracy. An Iranian medical professional in northern Iran said he and colleagues spent the early hours of Sunday celebrating Khamenei’s death indoors because armed security forces are still heavily deployed in his city. There were forces stopping and interrogating people celebrating in their cars but there was no gunfire, said the doctor, who spoke on condition of anonymity for fear of reprisal. “It was one of the best nights, if not the best night of our lives,” the doctor said in a voice message from the city of Rasht. In fact, “it w